A victory will see Liverpool record 13 away league wins to equal their second-highest ever tally in a single campaign.
They won 13 in 1904/05, 2008/09 and 2018/19, a tally only ever surpassed in 2019/20 (14).
Should they score five goals they will equal their highest total of away goals in a single season, having scored 48 in 2013/14.
If they score twice they will record 550 in the league under Jurgen Klopp and also hit the landmark of 250 in away league games.
Firmino to join the 100 club?
Roberto Firmino needs two goals to become the 19th Liverpool player to reach 100 goals in a career in all competitions.
Firmino has already scored two goals against Southampton, both coming in wins at St Mary’s.
Score first, never lose
Liverpool have not lost any of the 42 games this season in which they have scored the first goal of the game – 38 wins and four draws.
They are unbeaten in the last 16 games in all competitions (since a home defeat to Inter Milan in March) – winning 13 and drawing three – and in 17 in the league since defeat at Leicester on December 28.
The other five seasons were 1895/96, 1904/05, 1960/61, 1963/64 and 1987/88.
Ibrahima Konate has yet to suffer defeat in any of the 26 games he has played for Liverpool.
Martin Atkinson will take charge of Liverpool for the 74th and final time before he hangs up his whistle at the weekend.
The 51-year-old has refereed Liverpool more times than any other club in history, with the Reds winning 36 of those – including all four games this season.
He has also shown Liverpool more straight red cards (six) than any other club, but five – Chelsea (14), Aston Villa (12), Crystal Palace (11), Man City (nine) and Arsenal (seven) – have been awarded more penalties than their six.
This season’s scorers
Southampton: Ward-Prowse 10, Broja 9, Adams 8, Elyounoussi 8, Bednarek 4, S.Armstrong 3, Walker-Peters 3, own goals 3, A.Armstrong 2, Long 2, Redmond 2, Romeu 2, Diallo 1, Livramento 1, Perraud 1, Salisu 1, Tella 1
Liverpool: Salah 30, Mane 22, Jota 21, Firmino 11, Minamino 9, Fabinho 8, Diaz 6, Origi 6, Keita 4, Henderson 3, Konate 3, Oxlade-Chamberlain 3, Van Dijk 3, Alexander-Arnold 2, Matip 2, Robertson 2, Thiago 2, own goals 2, Elliott 1, Gordon 1, Jones 1